This is the part of Silverlight that I can grok as a developer of nary so flashy (pun intended) as much as practical pieces of software. The ability to put so many languages in concert, the development experience as text-based and interactive (edit text and refresh just like you do with HTML), and the cross platform support make my mind swim with potential uses. The fact that their demonstration was on a Mac was a brash in the best sense: it's a level of confidence that's not based on arrogance, but preference (Lam presented on a Macbook pro at Teched last year).
Although the Perl community is tremendous, it seems as fractured as 3rd century Rome. But that being said it's possible that either one of the monks or a clever company will start a project that makes it another language in the DLR family.
Or maybe I'll start a PerlCLR project and get hired by the b0rg. Not even in my dreams do I have skills like that ...